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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1588588
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tbk1
Name: TANK-binding kinase 1
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tbk1increases phosphorylationISOTbk1 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased phosphorylation of TBK1 proteinPMID:36583613
Tbk1multiple interactionsISOTbk1 (Mus musculus)6480464CTDLycopene inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of TBK1 protein]PMID:36583613
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