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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1583843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: S1pr3
Name: sphingosine-1-phosphate receptor 3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
S1pr3affects expressionISOS1pr3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of S1PR3 mRNAPMID:20702594
S1pr3decreases expressionISOS1pr3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of S1PR3 mRNAPMID:19933214
S1pr3increases expressionISOS1pr3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of S1PR3 mRNAPMID:21889950
S1pr3multiple interactionsISOS1pr3 (Mus musculus)6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of S1PR3 mRNAPMID:25975270
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