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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1565646
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sox2
Name: SRY-box transcription factor 2
Acc ID: CHEBI:5693
Term: hexachlorophene
Definition: An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union.
Chemical ID: MESH:D006582
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sox2decreases expressionISOSox2 (Mus musculus)6480464CTDHexachlorophene results in decreased expression of SOX2 mRNA; Hexachlorophene results in decreased expression of SOX2 proteinPMID:25943520
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