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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1565362
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Patj
Name: PATJ, crumbs cell polarity complex component
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Patjaffects methylationISOPATJ (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PATJ 5' UTR; Benzo(a)pyrene affects the methylation of PATJ exonPMID:27901495 PMID:30157460
Patjdecreases expressionISOPatj (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of PATJ mRNAPMID:21715664
Patjdecreases expressionISOPATJ (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of PATJ mRNAPMID:20106945 PMID:21632981 PMID:22316170 PMID:31255691 PMID:32234424
Patjdecreases methylationISOPATJ (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of PATJ promoterPMID:27901495
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