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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1561420
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il27
Name: interleukin 27
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il27increases expressionISOIL27 (Homo sapiens)6480464CTDSimvastatin results in increased expression of IL27 mRNAPMID:18453621
Il27increases secretionISOIL27 (Homo sapiens)6480464CTDSimvastatin results in increased secretion of IL27 proteinPMID:18453621
Il27multiple interactionsISOIL27 (Homo sapiens)6480464CTDIL27 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IL27 affects the reaction [Simvastatin results in decreased expression of RORC mRNA]; IL27 affects the reaction [Simvastatin results in decreased secretion of IL17A protein]PMID:18453621
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