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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1560340
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ercc4
Name: ERCC excision repair 4, endonuclease catalytic subunit
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ercc4decreases expressionISOERCC4 (Homo sapiens)6480464CTDArsenic results in decreased expression of ERCC4 mRNAPMID:12569548
Ercc4multiple interactionsISOERCC4 (Homo sapiens)6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of ERCC4 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of ERCC4 protein; trichostatin A inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of ERCC4 mRNA]; trichostatin A inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of ERCC4 protein]PMID:32031413
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