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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558093
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnbip1
Name: catenin beta interacting protein 1
Acc ID: CHEBI:68931
Term: bruceine D
Definition: A quassinoid that is 13,20-epoxypicras-3-ene substituted by hydroxy groups at positions 1, 11, 12, 14 and 15 and oxo groups at positions 2 and 16. Isolated from the ethanol extract of the stem of Brucea mollis, it exhibits cytotoxic activity.
Chemical ID: MESH:C030412
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctnnbip1affects bindingISOCTNNBIP1 (Homo sapiens)6480464CTDbruceine D binds to CTNNBIP1 proteinPMID:34900531
Ctnnbip1decreases expressionISOCTNNBIP1 (Homo sapiens)6480464CTDbruceine D results in decreased expression of CTNNBIP1 proteinPMID:34900531
Ctnnbip1multiple interactionsISOCTNNBIP1 (Homo sapiens)6480464CTDbruceine D inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of HK2 protein]]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of LDHA protein]]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of PKM protein]]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC16A3 protein]]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC2A1 protein]]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC2A3 protein]]; CTNNBIP1 protein affects the reaction [bruceine D inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]PMID:34900531
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