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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1557593
Species: Mus musculus
RGD Object: Gene
Symbol: Map3k11
Name: mitogen-activated protein kinase kinase kinase 11
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map3k11increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of MAP3K11 mRNAPMID:22228805
Map3k11multiple interactionsEXP 6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to MAP3K11 promoter]PMID:19654925
Map3k11decreases expressionISOMap3k11 (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in decreased expression of MAP3K11 mRNAPMID:21839799
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