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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553302
Species: Mus musculus
RGD Object: Gene
Symbol: Gnrh1
Name: gonadotropin releasing hormone 1
Acc ID: CHEBI:35004
Term: Tetrachlorobisphenol A
Definition: A bisphenol that has formula C15H12Cl4O2.
Chemical ID: MESH:C041181
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gnrh1decreases expressionEXP 6480464CTDtetrachlorodian results in decreased expression of GNRH1 mRNAPMID:37992829
Gnrh1decreases secretionEXP 6480464CTDtetrachlorodian results in decreased secretion of GNRH1 proteinPMID:37992829
Gnrh1multiple interactionsEXP 6480464CTDU 0126 inhibits the reaction [tetrachlorodian results in decreased expression of GNRH1 mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in decreased expression of GNRH1 mRNA]PMID:37992829
Gnrh1affects expressionISOGnrh1 (Rattus norvegicus)6480464CTDtetrachlorodian affects the expression of GNRH1 mRNAPMID:37992829
Gnrh1increases expressionISOGnrh1 (Rattus norvegicus)6480464CTDtetrachlorodian results in increased expression of GNRH1 proteinPMID:37992829
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