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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551988
Species: Mus musculus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Acc ID: CHEBI:29623
Term: manumycin A
Definition: A polyketide with formula C31H38N2O7 initially isolated from Streptomyces parvulus as a result of a random screening program for farnesyl transferase (FTase) inhibitors. It is a natural product that exhibits anticancer and antibiotic properties.
Chemical ID: MESH:C054474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDmanumycin results in increased cleavage of PARP1; manumycin results in increased cleavage of PARP1 proteinPMID:14625852 PMID:19409983
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [manumycin results in increased cleavage of PARP1]; Quercetin promotes the reaction [manumycin results in increased cleavage of PARP1 protein]PMID:14625852 PMID:19409983
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