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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551392
Species: Mus musculus
RGD Object: Gene
Symbol: Mthfr
Name: methylenetetrahydrofolate reductase
Acc ID: CHEBI:20502
Term: 5,10-methylenetetrahydrofolic acid
Definition: A methylenetetrahydrofolic acid that has formula C20H23N7O6.
Chemical ID: MESH:C013123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mthfrincreases metabolic processingISOMTHFR (Homo sapiens)6480464CTDMTHFR protein results in increased metabolism of 5,10-methylenetetrahydrofolic acidPMID:16187112
Mthfrincreases reductionISOMTHFR (Homo sapiens)6480464CTDMTHFR protein results in increased reduction of 5,10-methylenetetrahydrofolic acidPMID:7647779
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