Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1551392
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Mthfr
Name:	methylenetetrahydrofolate reductase

Acc ID:	CHEBI:166565
Term:	7-Hydroxymethotrexate
Definition:	null
Chemical ID:	MESH:C011864

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Mthfr	decreases response to substance	ISO	MTHFR (Homo sapiens)	6480464	CTD	MTHFR mRNA results in decreased susceptibility to 7-hydroxymethotrexate	PMID:19426680

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.