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GENE - TERM ANNOTATION REPORT

RGD ID: 1551142
Species: Mus musculus
RGD Object: Gene
Symbol: Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Acc ID: DOID:9007096
Term: Stroke
Definition: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Definition Source(s): MESH:D020521
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3ca ISOPIK3CA (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: StrokePMID:15520168 PMID:22658544 PMID:22729222 PMID:23100325 PMID:23946963 PMID:25599672 PMID:25681199 PMID:25741868 PMID:26627007 PMID:27631024 PMID:29446767 PMID:34496175 PMID:34568242 PMID:34606700 PMID:37667289
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