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GENE - TERM ANNOTATION REPORT

RGD ID: 14258037
Species: Sus scrofa
RGD Object: Gene
Symbol: SLC6A4
Name: solute carrier family 6 member 4
Acc ID: GO:0045202
Term: synapse
Definition: The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
Definition Source(s): GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC6A4located_inIEAUniProtKB:Q60857 or ensembl:ENSMUSP00000104039150520179Ensembl GO_REF:0000107
SLC6A4is_active_inIBAFB:FBgn0010414 or MGI:96285 or PANTHER:PTN002481010 or Slc6a4 (Rattus norvegicus)150520179GO_Central GO_REF:0000033
SLC6A4located_inIEAUniProtKB-KW:KW-0770150520179UniProt GO_REF:0000043
SLC6A4located_inIEAUniProtKB-SubCell:SL-0258150520179UniProt GO_REF:0000044
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