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GENE - TERM ANNOTATION REPORT

RGD ID: 14256575
Species: Sus scrofa
RGD Object: Gene
Symbol: JAK3
Name: Janus kinase 3
Acc ID: DOID:8761
Term: acute megakaryocytic leukemia
Definition: An acute myeloid leukemia that derives from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers. (DO)
Definition Source(s): https://en.wikipedia.org/wiki/Acute_megakaryoblastic_leukemia "DO" "DO", https://pubmed.ncbi.nlm.nih.gov/26228843/ "DO" "DO", https://www.orpha.net/data/patho/GB/uk-AMLM7.pdf "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
JAK3 ISOJAK3 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute megakaryoblastic leukemia | ClinVar Annotator: match by term: Acute megakaryocytic leukemiaPMID:10982185 PMID:16843266 PMID:18270328 PMID:18397343 PMID:20132407 PMID:20372971 PMID:20385788 PMID:20400977 PMID:21599579 PMID:21821710 PMID:22271575 PMID:24728327 PMID:25157968 PMID:25741868 PMID:28492532
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