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GENE - TERM ANNOTATION REPORT

RGD ID: 14098222
Species: Sus scrofa
RGD Object: Gene
Symbol: IL6
Name: interleukin 6
Acc ID: DOID:3083
Term: chronic obstructive pulmonary disease
Definition: An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both. (DO)
Definition Source(s): https://pubmed.ncbi.nlm.nih.gov/28513453/ "DO" "DO", https://pubmed.ncbi.nlm.nih.gov/32745458/ "DO" "DO", https://pubmed.ncbi.nlm.nih.gov/32800196/ "DO" "DO", https://www.nhlbi.nih.gov/health/copd "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL6 ISOIL6 (Homo sapiens)9068941RGDprotein:increased expression:plasmaPMID:20819268 REF_RGD_ID:4143243
IL6 ISOIL6 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:28864214 PMID:29329563 PMID:31349846
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