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GENE - TERM ANNOTATION REPORT

RGD ID: 14098222
Species: Sus scrofa
RGD Object: Gene
Symbol: IL6
Name: interleukin 6
Acc ID: DOID:10608
Term: celiac disease
Definition: An autoimmune disease of gastrointestinal tract that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Coeliac_disease "DO" "DO", http://www.celiac.org/ "DO" "DO", http://www.mayoclinic.com/health/celiac-disease/DS00319 "DO" "DO", http://www.nlm.nih.gov/medlineplus/ency/article/000233.htm "DO" "DO", https://www.niddk.nih.gov/health-information/digestive-diseases/celiac-disease "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL6 ISOIL6 (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Insulin-Dependent; DNA:polymorphism:promoter:-174G>C (human)PMID:18692934 REF_RGD_ID:2307292
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