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GENE - TERM ANNOTATION REPORT

RGD ID: 14057153
Species: Sus scrofa
RGD Object: Gene
Symbol: RUVBL2
Name: RuvB like AAA ATPase 2
Acc ID: GO:0097255
Term: R2TP complex
Definition: A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.
Definition Source(s): GOC:mcc, PMID:15766533, PMID:21925213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RUVBL2located_inISORUVBL2 (Homo sapiens)9068941ComplexPortal PMID:29662061

PMID:29662061
RUVBL2part_ofIEAUniProtKB:Q9Y230 or ensembl:ENSP00000473172150520179Ensembl GO_REF:0000107
RUVBL2part_ofIBAFB:FBgn0040075 or FB:FBgn0040078 or PANTHER:PTN000120244 or SGD:S000002598 or SGD:S000006156 or UniProtKB:Q9Y230 or UniProtKB:Q9Y265150520179GO_Central GO_REF:0000033
RUVBL2part_ofIEAPANTHER:PTHR11093:SF2150520179TreeGrafter GO_REF:0000118
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