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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359694
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rap1a
Name: RAP1A, member of RAS oncogene family
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rap1adecreases expressionISORAP1A (Homo sapiens)6480464CTDSimvastatin results in decreased expression of RAP1A protein alternative formPMID:37956312
Rap1adecreases geranoylationISORAP1A (Homo sapiens)6480464CTDSimvastatin results in decreased geranoylation of RAP1A proteinPMID:25578243
Rap1adecreases prenylationISORAP1A (Homo sapiens)6480464CTDSimvastatin results in decreased prenylation of RAP1A proteinPMID:20018177 PMID:37956312
Rap1adecreases prenylationISORap1a (Mus musculus)6480464CTDSimvastatin results in decreased prenylation of RAP1A proteinPMID:20018177
Rap1amultiple interactionsISORAP1A (Homo sapiens)6480464CTDMevalonic Acid inhibits the reaction [Simvastatin results in decreased geranoylation of RAP1A protein]; Simvastatin results in decreased geranoylation of and results in decreased prenylation of RAP1A proteinPMID:22120639 PMID:25578243
Rap1amultiple interactionsISORap1a (Mus musculus)6480464CTDSimvastatin results in decreased geranoylation of and results in decreased prenylation of RAP1A proteinPMID:22120639
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