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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359491
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pou5f1
Name: POU class 5 homeobox 1
Acc ID: CHEBI:18258
Term: 3,3',5-triiodo-L-thyronine
Definition: An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Chemical ID: MESH:D014284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pou5f1increases expressionISOPou5f1 (Mus musculus)6480464CTDTriiodothyronine results in increased expression of POU5F1 mRNAPMID:34571837
Pou5f1multiple interactionsISOPou5f1 (Mus musculus)6480464CTDChlorpyrifos inhibits the reaction [Triiodothyronine results in increased expression of POU5F1 mRNA]; Ethylenethiourea inhibits the reaction [Triiodothyronine results in increased expression of POU5F1 mRNA]PMID:34571837
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