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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359152
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl7
Name: C-C motif chemokine ligand 7
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl7increases expressionISOCcl7 (Mus musculus)6480464CTDOzone results in increased expression of CCL7 mRNA; Ozone results in increased expression of CCL7 proteinPMID:11777981 PMID:18929643 PMID:30848106
Ccl7increases response to substanceISOCcl7 (Mus musculus)6480464CTDCCL7 protein results in increased susceptibility to OzonePMID:11777981
Ccl7multiple interactionsISOCcl7 (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of CCL7 mRNA; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of CCL7 mRNA; [NOTCH3 gene mutant form affects the susceptibility to Ozone] which affects the expression of CCL7 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of CCL7 mRNAPMID:25658374 PMID:27106289 PMID:34911549
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