GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | increases degradation | EXP | | 6480464 | CTD | CYP3A4 protein results in increased degradation of Ticlopidine | PMID:22651985 | CYP3A4 | increases response to substance | EXP | | 6480464 | CTD | CYP3A4 protein results in increased susceptibility to Ticlopidine | PMID:22651985 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | CYP3A4 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Ticlopidine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Ticlopidine]; Ticlopidine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | PMID:19170597 PMID:19299527 PMID:22651985 | | ||||||||||||||||||||||
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