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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:95129
Term: 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide
Definition: A benzamide that has formula C23H29ClFN3O4.
Chemical ID: MESH:D020117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4affects chemical synthesisEXP 6480464CTDCYP3A4 protein affects the chemical synthesis of Cisapride metabolitePMID:11717173
CYP3A4affects metabolic processingEXP 6480464CTDCYP3A4 protein affects the metabolism of CisapridePMID:11717173
CYP3A4decreases activityEXP 6480464CTDCisapride results in decreased activity of CYP3A4 proteinPMID:15306208
CYP3A4multiple interactionsEXP 6480464CTDCisapride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]PMID:19299527
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