GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | affects metabolic processing | EXP | | 6480464 | CTD | CYP3A4 protein affects the metabolism of Terfenadine | PMID:15383492 | CYP3A4 | increases degradation | EXP | | 6480464 | CTD | CYP3A4 protein results in increased degradation of Terfenadine | PMID:15684493 | CYP3A4 | increases expression | EXP | | 6480464 | CTD | Terfenadine analog results in increased expression of CYP3A4 mRNA | PMID:12505310 | CYP3A4 | increases metabolic processing | EXP | | 6480464 | CTD | CYP3A4 protein results in increased metabolism of Terfenadine | PMID:15869686 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Terfenadine]; Terfenadine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | PMID:15869686 PMID:19299527 | |
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