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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:81763
Term: fludioxonil
Definition: A member of the class of benzodioxoles that is 2,2-difluoro-1,3-benzodioxole substituted at position 4 by a 3-cyanopyrrol-4-yl group. A fungicide seed treatment for control of a range of diseases including Fusarium, Rhizoctonia and Alternaria.
Chemical ID: MESH:C108339
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4decreases activityEXP 6480464CTDfludioxonil results in decreased activity of CYP3A4 proteinPMID:33575850
CYP3A4multiple interactionsEXP 6480464CTD[procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNAPMID:25028461
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