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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:80706
Term: Aflatoxin G1
Definition: A coumarin that has formula C17H12O7.
Chemical ID: MESH:C027955
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4affects metabolic processingEXP 6480464CTDCYP3A4 protein affects the metabolism of aflatoxin G1PMID:2271712 PMID:2655891
CYP3A4increases expressionEXP 6480464CTDaflatoxin G1 results in increased expression of CYP3A4 mRNAPMID:21641981
CYP3A4increases response to substanceEXP 6480464CTDCYP3A4 protein results in increased susceptibility to aflatoxin G1PMID:11189750
CYP3A4multiple interactionsEXP 6480464CTDaflatoxin G1 promotes the reaction [NR1I2 protein binds to CYP3A4 promoter]PMID:21641981
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