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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:7915
Term: pantoprazole
Definition: A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a difluoromethoxy group at position 5 and a [(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl group at position 2.
Chemical ID: MESH:C064276
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4increases expressionEXP 6480464CTDpantoprazole results in increased expression of CYP3A4 proteinPMID:9744552
CYP3A4increases metabolic processingEXP 6480464CTDCYP3A4 protein results in increased metabolism of pantoprazolePMID:8930576
CYP3A4multiple interactionsEXP 6480464CTDpantoprazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]PMID:15258107
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