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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4decreases expressionEXP 6480464CTDochratoxin A results in decreased expression of CYP3A4 mRNAPMID:26505656
CYP3A4increases expressionEXP 6480464CTDochratoxin A results in increased expression of CYP3A4 mRNA; ochratoxin A results in increased expression of CYP3A4 proteinPMID:21834667 PMID:30291945
CYP3A4increases response to substanceEXP 6480464CTDCYP3A4 protein results in increased susceptibility to ochratoxin APMID:21781659 PMID:8542584
CYP3A4multiple interactionsEXP 6480464CTDochratoxin A inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; ochratoxin A inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]PMID:26341324
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