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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:7071
Term: N,N-diethyl-m-toluamide
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of m-toluic acid with the nitrogen of diethylamine. First developed by the U.S. Army in 1946 for use by military personnel in insect-infested areas, it is the most widely used insect repellent worldwide.
Chemical ID: MESH:D003671
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4increases expressionEXP 6480464CTDDEET results in increased expression of CYP3A4 mRNAPMID:19326769 PMID:27091632 PMID:36356836
CYP3A4increases metabolic processingEXP 6480464CTDCYP3A4 protein results in increased metabolism of DEETPMID:11854147
CYP3A4multiple interactionsEXP 6480464CTD[fipronil co-treated with DEET] results in increased expression of CYP3A4 mRNAPMID:27091632
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