GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | decreases expression | EXP | | 6480464 | CTD | Metformin results in decreased expression of CYP3A4 mRNA | PMID:21920351 | CYP3A4 | increases expression | EXP | | 6480464 | CTD | Metformin results in increased expression of CYP3A4 mRNA | PMID:19022234 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] | PMID:21920351 | |
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