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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:5294
Term: Gelsemine
Definition: An indole alkaloid that has formula C20H22N2O2.
Chemical ID: MESH:C063230
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4decreases response to substanceEXP 6480464CTDCYP3A4 protein results in decreased susceptibility to gelseminePMID:34627953
CYP3A4increases metabolic processingEXP 6480464CTDCYP3A4 protein results in increased metabolism of gelseminePMID:34627953
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