GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | decreases response to substance | EXP | | 6480464 | CTD | CYP3A4 protein results in decreased susceptibility to dronedarone | PMID:29616291 | CYP3A4 | increases metabolic processing | EXP | | 6480464 | CTD | CYP3A4 protein results in increased metabolism of Dronedarone | PMID:29616291 PMID:31756459 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | [CYP3A4 protein results in increased metabolism of Dronedarone] which results in increased abundance of N-desbutyldronedarone; [CYP3A4 protein results in increased metabolism of Dronedarone] which results in increased chemical synthesis of N-desbutyldronedarone; CYP3A4 protein inhibits the reaction [Dronedarone results in decreased expression of TOP2A protein]; CYP3A4 protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein] | PMID:29616291 PMID:31756459 | | ||||||||||||||||||||||
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