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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:4470
Term: dextromethorphan
Definition: A 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough.
Chemical ID: MESH:D003915
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4affects metabolic processingEXP 6480464CTDCYP3A4 protein affects the metabolism of DextromethorphanPMID:15988119
CYP3A4decreases methylationEXP 6480464CTDCYP3A4 protein results in decreased methylation of DextromethorphanPMID:15383492
CYP3A4increases metabolic processingEXP 6480464CTDCYP3A4 protein results in increased metabolism of DextromethorphanPMID:16595712 PMID:17267297
CYP3A4increases oxidationEXP 6480464CTDCYP3A4 protein results in increased oxidation of DextromethorphanPMID:15383492
CYP3A4multiple interactionsEXP 6480464CTDDextromethorphan inhibits the reaction [[retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein]PMID:19818743
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