GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | increases activity | EXP | | 6480464 | CTD | flavone results in increased activity of CYP3A4 protein | PMID:31756459 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | [[flavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [flavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; flavone binds to and results in decreased activity of CYP3A4 protein; flavone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; flavone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] | PMID:21053930 PMID:31756459 | | ||||||||||||||||||||||
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