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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:42355
Term: erythromycin A
Definition: An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.
Chemical ID: MESH:D004917
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4affects metabolic processingEXP 6480464CTDCYP3A4 protein affects the metabolism of ErythromycinPMID:8114683
CYP3A4decreases activityEXP 6480464CTDErythromycin results in decreased activity of CYP3A4 proteinPMID:15466163 PMID:15845683 PMID:16041596 PMID:16042670 PMID:16416302
CYP3A4decreases methylationEXP 6480464CTDCYP3A4 protein results in decreased methylation of ErythromycinPMID:15383492 PMID:2271712
CYP3A4increases expressionEXP 6480464CTDErythromycin results in increased expression of CYP3A4 mRNA; Erythromycin results in increased expression of CYP3A4 proteinPMID:18505790
CYP3A4increases metabolic processingEXP 6480464CTDCYP3A4 protein results in increased metabolism of ErythromycinPMID:21466820
CYP3A4multiple interactionsEXP 6480464CTDErythromycin inhibits the reaction [CYP3A4 protein affects the metabolism of brotizolam]; Erythromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide]; Erythromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Teniposide]; Erythromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; Erythromycin inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; IFNA protein inhibits the reaction [CYP3A4 protein results in increased metabolism of Erythromycin]PMID:16042670 PMID:16416302 PMID:19299527 PMID:21466820 PMID:8114683
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