GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | decreases expression | EXP | | 6480464 | CTD | Curcumin results in decreased expression of CYP3A4 mRNA | PMID:20816778 | CYP3A4 | increases expression | EXP | | 6480464 | CTD | Curcumin results in increased expression of CYP3A4 mRNA | PMID:17210444 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; Curcumin inhibits the reaction [Calcitriol results in increased expression of and results in increased activity of CYP3A4 protein]; Curcumin inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; Curcumin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] | PMID:17270371 PMID:17965521 PMID:18385293 PMID:20153625 | |
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