GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | decreases activity | EXP | | 6480464 | CTD | fluvastatin results in decreased activity of CYP3A4 protein | PMID:16029222 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | [fluvastatin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA; fluvastatin inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam] | PMID:16029222 PMID:24204015 | |
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