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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:3647
Term: chlorpromazine
Definition: A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Chemical ID: MESH:D002746
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4affects methylationEXP 6480464CTDCYP3A4 protein affects the methylation of ChlorpromazinePMID:20615392
CYP3A4affects oxidationEXP 6480464CTDCYP3A4 protein affects the oxidation of ChlorpromazinePMID:20615392
CYP3A4decreases activityEXP 6480464CTDChlorpromazine results in decreased activity of CYP3A4 proteinPMID:15135088
CYP3A4decreases response to substanceEXP 6480464CTDCYP3A4 protein results in decreased susceptibility to ChlorpromazinePMID:26477383
CYP3A4multiple interactionsEXP 6480464CTD[Chlorpromazine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to ChlorpromazinePMID:17041008 PMID:23397584
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