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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:34911
Term: permethrin
Definition: A cyclopropanecarboxylate ester in which the esterifying alcohol is 3-phenoxybenzyl alcohol and the cyclopropane ring is substituted with a 2,2-dichlorovinyl group and with gem-dimethyl groups.
Chemical ID: MESH:D026023
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4decreases activityEXP 6480464CTDPermethrin results in decreased activity of CYP3A4 proteinPMID:16790556 PMID:21924250
CYP3A4increases expressionEXP 6480464CTDPermethrin results in increased expression of CYP3A4 mRNAPMID:19249324 PMID:19326768
CYP3A4increases metabolic processingEXP 6480464CTDCYP3A4 protein results in increased metabolism of PermethrinPMID:24548679
CYP3A4multiple interactionsEXP 6480464CTD[Permethrin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Permethrin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Permethrin inhibits the reaction [CYP3A4 protein results in increased metabolism of Estradiol]PMID:16790556 PMID:31312845
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