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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:34562
Term: Benzo[a]pyrene-7,8-diol
Definition: A pyrene that has formula C20H14O2.
Chemical ID: MESH:C017228
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4affects metabolic processingEXP 6480464CTDCYP3A4 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiolPMID:2271712 PMID:2655891
CYP3A4multiple interactionsEXP 6480464CTD[benzo(a)pyrene 7,8-dihydrodiol binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; [CYP3A4 protein results in increased metabolism of Benzo(a)pyrene] which results in increased chemical synthesis of benzo(a)pyrene 7,8-dihydrodiol; CYP3A4 protein results in increased metabolism of and results in increased activity of benzo(a)pyrene 7,8-dihydrodiolPMID:23845848 PMID:2509067
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