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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:3388
Term: carbamazepine-10,11-epoxide
Definition: An epoxide and metabolite of carbamazepine.
Chemical ID: MESH:C012227
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4affects chemical synthesisEXP 6480464CTDCYP3A4 protein affects the chemical synthesis of carbamazepine epoxidePMID:15915352
CYP3A4multiple interactionsEXP 6480464CTD[CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide; felbamate affects the reaction [[CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide]; Probenecid promotes the reaction [CYP3A4 protein affects the chemical synthesis of carbamazepine epoxide]PMID:12606595 PMID:15915352
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