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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:3223
Term: buspirone
Definition: An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.
Chemical ID: MESH:D002065
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4increases metabolic processingEXP 6480464CTDCYP3A4 protein results in increased metabolism of BuspironePMID:20716633
CYP3A4increases oxidationEXP 6480464CTDCYP3A4 protein results in increased oxidation of BuspironePMID:15640381
CYP3A4multiple interactionsEXP 6480464CTDresveratrol inhibits the reaction [CYP3A4 protein results in increased metabolism of Buspirone]PMID:20716633
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