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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:2955
Term: azithromycin
Definition: A macrolide antibiotic useful for the treatment of bacterial infections.
Chemical ID: MESH:D017963
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4decreases activityEXP 6480464CTDAzithromycin results in decreased activity of CYP3A4 proteinPMID:16416302
CYP3A4multiple interactionsEXP 6480464CTDAzithromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]PMID:16416302
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