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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:2679
Term: amphetamine
Definition: A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
Chemical ID: MESH:D000661
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4affects chemical synthesisEXP 6480464CTDCYP3A4 protein affects the chemical synthesis of AmphetaminePMID:15294457
CYP3A4decreases alkylationEXP 6480464CTDCYP3A4 protein results in decreased alkylation of Amphetamine analogPMID:29277574
CYP3A4decreases methylationEXP 6480464CTDCYP3A4 protein results in decreased methylation of Amphetamine analogPMID:29277574
CYP3A4multiple interactionsEXP 6480464CTDAmphetamine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Amphetamine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]PMID:21402137
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