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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:2533
Term: alachlor
Definition: An aromatic amide that is N-(2,6-diethylphenyl)acetamide substituted by a methoxymethyl group at at the nitrogen atom while one of the hydrogens of the methyl group has been replaced by a chlorine atom.
Chemical ID: MESH:C000188
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4increases expressionEXP 6480464CTDalachlor results in increased expression of CYP3A4 mRNAPMID:16565514
CYP3A4increases metabolic processingEXP 6480464CTDCYP3A4 protein results in increased metabolism of alachlorPMID:10475613 PMID:18273908
CYP3A4multiple interactionsEXP 6480464CTD[CYP3A4 protein results in increased metabolism of alachlor] which results in increased abundance of 2-chloro-N-(2,6-diethylphenyl)acetamidePMID:18273908
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