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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4increases expressionEXP 6480464CTDProgesterone results in increased expression of CYP3A4 mRNAPMID:22837389
CYP3A4increases hydroxylationEXP 6480464CTDCYP3A4 protein results in increased hydroxylation of ProgesteronePMID:18957504
CYP3A4multiple interactionsEXP 6480464CTDProgesterone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]PMID:19299527
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