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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4decreases activityEXP 6480464CTDQuercetin results in decreased activity of CYP3A4 proteinPMID:15266218 PMID:18420780 PMID:19766177 PMID:21053930 PMID:28232125 PMID:29753067
CYP3A4increases expressionEXP 6480464CTDQuercetin results in increased expression of CYP3A4 mRNA; Quercetin results in increased expression of CYP3A4 proteinPMID:12695340 PMID:15266218 PMID:16442130 PMID:26238175 PMID:26366751
CYP3A4multiple interactionsEXP 6480464CTD[Quercetin results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine; Quercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Quercetin inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein]; Quercetin inhibits the reaction [CYP3A4 protein results in increased degradation of Hydrocortisone]; VDR promotes the reaction [Quercetin results in increased expression of CYP3A4 mRNA]PMID:11502731 PMID:15266218 PMID:19766177 PMID:24120545 PMID:26366751
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