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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:10100
Term: zafirlukast
Definition: A N-sulfonylcarboxamide that has formula C31H33N3O6S.
Chemical ID: MESH:C062735
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4decreases activityEXP 6480464CTDzafirlukast metabolite results in decreased activity of CYP3A4 protein; zafirlukast results in decreased activity of CYP3A4 proteinPMID:15370959 PMID:16167835
CYP3A4increases metabolic processingEXP 6480464CTDCYP3A4 protein results in increased metabolism of zafirlukastPMID:16167835
CYP3A4multiple interactionsEXP 6480464CTDzafirlukast inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]PMID:15370959
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