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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350492
Species: Homo sapiens
RGD Object: Gene
Symbol: CYBB
Name: cytochrome b-245 beta chain
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYBBincreases expressionEXP 6480464CTDParaquat results in increased expression of CYBB mRNAPMID:34097952
CYBBmultiple interactionsEXP 6480464CTD[Paraquat co-treated with Maneb] results in increased expression of CYBB mRNA; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB mRNA]; diphenyleneiodonium inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB mRNA]PMID:30797899
CYBBmultiple interactionsISOCybb (Mus musculus)6480464CTD[Maneb co-treated with Paraquat] results in increased expression of CYBB protein; [Paraquat co-treated with Maneb] results in increased expression of CYBB protein; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CYBB protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein]PMID:29568078 PMID:32375810 PMID:34052309
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