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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349272
Species: Homo sapiens
RGD Object: Gene
Symbol: PON1
Name: paraoxonase 1
Acc ID: CHEBI:46557
Term: zoledronic acid
Definition: An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.
Chemical ID: MESH:C088658
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PON1increases activityISOPon1 (Rattus norvegicus)6480464CTDzoledronic acid results in increased activity of PON1 proteinPMID:27387541
PON1multiple interactionsISOPon1 (Rattus norvegicus)6480464CTD[zoledronic acid results in increased activity of PON1 protein] which results in increased metabolism of phenyl acetatePMID:27387541
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